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AI Agent Frameworks in 2026: OpenAI Agents SDK vs Anthropic MCP

By TLDL

Compare the top AI agent frameworks in 2026. Learn about OpenAI's Agents SDK, Anthropic's MCP protocol, and which ecosystem to bet on.

AI Agent Frameworks in 2026: OpenAI Agents SDK vs Anthropic MCP

The agent framework war is heating up. OpenAI released their Agents SDK while Anthropic pushed MCP (Model Context Protocol) to the Linux Foundation. Here's what matters.

The Two Ecosystems

OpenAI Agents SDK

  • Philosophy: Full-stack, batteries included
  • Built-in tools: Web Search, File Search, Computer Use
  • Strength: Tight integration with OpenAI models
  • Migration: Assistants API sunsetting in 2026

Anthropic MCP (Model Context Protocol)

  • Philosophy: Open standard, interoperability
  • Adoption: Donated to Linux Foundation
  • Supporters: OpenAI, Google, Microsoft all adopted
  • Strength: Tool-agnostic, cross-platform

Why This Matters

The battle mirrors the "iOS vs Android" of AI agents:

OpenAI approach:

  • Integrated experience
  • Easier to get started
  • Locked into OpenAI ecosystem

Anthropic approach:

  • Open standard
  • More flexibility
  • Works with any model

The Key Insight

From recent podcasts:

"The companies winning aren't just building better models. They're building better developer tools and protocols."

MCP is becoming the "USB-C of AI agents" - a universal standard for connecting AI to tools.

Framework Comparison

Feature OpenAI Agents SDK Anthropic MCP
Standard Proprietary Open (Linux Foundation)
Model lock-in Yes (OpenAI) No (any model)
Learning curve Low Medium
Tool ecosystem Growing Expanding
Enterprise ready Yes Yes

Which to Choose

Choose OpenAI Agents SDK if:

  • You want fastest time to market
  • You're already in OpenAI ecosystem
  • You don't need multi-model flexibility

Choose MCP if:

  • You want vendor independence
  • You need cross-platform tools
  • You're building for enterprise

The Bigger Picture

The winner might not be either framework - it might be the standard (MCP) that everyone adopts. As one podcast noted: "MCP is becoming the USB-C of AI agents."


Stay ahead of AI trends. tldl summarizes podcasts from builders and investors in the AI space.

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